Nucleotide sequences coding for the citE gene

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S106000, C435S232000, C536S023200

Reexamination Certificate

active

07129066

ABSTRACT:
The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the groupa) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2,b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2,c) polynucleotide that is complementary to the polynucleotides of a) or b), andd) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c),and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.

REFERENCES:
patent: 1 108 790 (2001-06-01), None
patent: 56 88 799 (1981-07-01), None
patent: 56-88799 (1981-07-01), None
patent: WO 01 00844 (2001-01-01), None
Kalinowski et al. (2003) Journal of Bacteriology, vol. 104, pp. 5-25.
Jakoby et al., “AmtR, a global repressor in the nitrogen regulation system ofCorynebacterium glutamicum”, Molecular Biology, vol. 37, Nr. 4, p. 964-977 & Database EMBL, Accession No. AJ133719, XP002176655.
Database EMBL, Accession No. AX127145; AX114121, Nakagawa et al., “Sequence 7061 from patent EP1108790”, 2001.
Database EMBL, Accession No. AX121047; Nakagawa et al., “Sequence 963 from patent EP1108790”, 2001.
Database EMBL, Accession No. AX124547, Nakagawa et al., “Sequence 4463 from patent EP1108790”, 2001.
Database EMBL, Accession No. AX121046, Nakagawa et al., “Sequence 962 from patent EP1108790”, 2001.
Database EMBL, Accession No. AX121048, Nakagawa et al., “Sequence 964 from patent EP1108790”, 2001.

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