Nucleotide sequence of gene specifically expressed in insulinoma

Details Nucleotide sequence of gene specifically expressed in insulinoma Nucleotide sequence of gene specifically expressed in insulinoma

1990-12-18

1993-08-31

Furman, Keith C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530806, 435 693, C07K 1506

Patent

active

052410501

ABSTRACT:
From a cDNA library, a nucleotide sequence of a novel gene, called rig, specifically expressed by streptozotocin- or alloxan-nicotinamide-induced rat insulinomas was determined and an amino acid sequence of a protein encoded by the gene was deduced. Further, novel genes with base sequences homologous to rig were found in a BK virus-induced hamster insulinoma and in a surgically removed human insulinoma. The above DNA is transcribed to provide an mRNA. The above novel proteins, DNAs and mRNAs can be efficaciously employed for the medical purposes of pancreatic diseases.

REFERENCES:
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Inoue et al. 1987, Proc. Natl. Acad. Sci. 84:6659-6662.
Duguid et al. 1978 Proc. Natl. Acad. Sci. 75(7):3249-3253.
Lerner, R. 1982, Nature 299: 592-596.
Lerner, R. A. 1984, Advances in Immunology 36: 1-49.
Chemical Abstracts, vol. 89, No. 13, Sep. 25, 1978, p. 283, abstract #102160g, Columbus, Ohio, US; J. R. Duguid et al.: "Identification of the major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma", Proc. Natl. Acad. Sci. USA 1978, 75(7), 3249-.
Chemical Abstracts, vol. 89, No. 9, Aug. 28, 1978, p. 162, abstract #72225n, Columbus, Ohio, US; M. A. Permutt et al., "Cell-free translation of messenger extracted from a human insulinoma", J. Clin. Endocrinol. Metab. 1978, 46(6).
Chemical Abstracts, vol. 106, No. 3, Jan. 19, 1987, p. 178, abstract #13898f, Columbus, Ohio, US; S. Takasawa et al.: "Novel gene activated in rat insulinomas", Diabetes 1986, 35(10), 1178-1180.

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