Nucleotide sequence of gene specifically expressed by insulinoma

Details Nucleotide sequence of gene specifically expressed by insulinoma Nucleotide sequence of gene specifically expressed by insulinoma

1987-08-21

1991-02-19

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 436501, 536 26, C07H 1512, C07H 1906, C12Q 168, G01N 33566

Patent

active

049945653

ABSTRACT:
From a cDNA library, a nucleotide sequence of a novel gene, called rig, specifically expressed by streptozotocin- or alloxan-nicotinamide-induced rat insulinomas was determined. Further, novel genes with base sequences homologous to rig were found in a BK virus-induced hamster insulinoma and in a surgically removed human insulinoma. The above DNA is transcribed to provide an mRNA. The above DNAs and mRNAs can be efficaciously employed for the medical purposes of pancreatic diseases.

REFERENCES:
Chemical Abstracts, vol. 89, No. 13, 9-25-78, p. 283, Abstract #102160q, J. R. Duguid et al: "Identification of the Major Polyadenylated Transcription Products and the Genes Active in Their Synthesis in a Rat Insulinoma," Proc. Natl Acad Sci U.S.A., 1978, 75(7), 3249-53.
Chemical Abstracts, vol. 89, No. 9, 8-28-78, p. 162, Abstract #72225n, M. A. Permutt et al: "Cell-Free Translation of Messenger RNA Extracted from a Human Insulinoma," J. Clin. Endocrinol. Metab. 1978, 46(6).
Chemical Abstracts, vol. 106, No. 3, 1-19-87, p. 178, Abstract #13898f, Columbus, Ohio, U.S. F. S. Takasawa et al: "Novel Gene Activated in Rat Insulinomas," Diabetes, 1986, 35(10), 1178-80.

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