Nucleotide sequence encoding human cyclin A

Details Nucleotide sequence encoding human cyclin A Nucleotide sequence encoding human cyclin A

1998-12-15

2000-08-15

Johnson, Nancy A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 241, 536 242, 4353201, C07H 2104, C12N 1511, C12N 1563

Patent

active

061038873

ABSTRACT:
The invention is directed generally to a DNA sequence coding for human cyclin A and in particular to antibodies, or antisera including such antibodies, which bind to human cyclin A as encoded by the sequence of SEQ ID NO: 1 and which are useful in detecting cellular proliferation. The antibodies of the invention can be polyclonal or monoclonal, and are preferably generated by injection of purified human cyclin A into an animal host. The invention is particularly advantageous because it has been discovered that the gene encoding for human cyclin A is a site for integration of the hepatitis B virus associated with hepatocellular carcinoma, and by detecting human cyclin A through the use of the antibodies of the invention, one can detect and diagnose cell proliferation. Through the use of the present invention, cell proliferation and tumorigenesis can thus be detected at early stages, and such conditions can then be treated or inhibited by the use of anti-sense human cyclin A DNA.

REFERENCES:
patent: 4544545 (1985-10-01), Ryan et al.
Alberts, Bruce et al. Molecular Biology of the Cell, second edition, pp. 95-97, 1989.
Wang, Jian et al. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343:555-557, 1990.
Xu, Li et al. Factors affecting Long-term Stability of Moloney Murine Leukemia virus-Based Vectors, Virology 171:331-341, 1989.

Affiliated with

Also associated with

Rating

Nucleotide sequence encoding human cyclin A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleotide sequence encoding human cyclin A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleotide sequence encoding human cyclin A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2008317