Nucleotide sequence encoding corynebacterium glutamicum...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S252330, C435S320100, C536S023700, C536S024320, C536S024300

Reexamination Certificate

active

07132272

ABSTRACT:
The present invention relates to an isolated polynucleotide coding for the lrp gene and to a process for the fermentative production of L-amino acids by altering the expression of this gene.

REFERENCES:
patent: 2005/0153402 (2005-07-01), Pompejus et al.
patent: 0 197 335 (1986-10-01), None
patent: WO 99/18228 (1999-04-01), None
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Witkowski et al. (1999) Biochemistry 38:11643-11650.
Database GenBank Accession No. B60643, Jun. 1998.
King and O'Brian, “Identification of Irp gene in Bradyrhizobium japonicum and its role in regulation of δ-aminolevulinic acid uptake”, Journal of Bacteriology, vol. 179, No. 5, p. 1828-1831, 1997.
Janes et al., “Two roles for the leucine-responsive regulatory protein in expression of the alanine catabolic operon (dadAB) in Klebsiella aerogenes”. Journal of Bacteriology, vol. 181, No. 3, p. 1054-1058, 1999.
Charlier et al., “Cloning and identification of the Sulfolobus solfataricus Irp gene encoding an archaeal homologue of the eurobacterial leucine-responsive global transcriptional regulator Lrp.”, Gene, 201, p. 63-68, 1997.
Belitsky et al., “An Irp-like gene of Bacillus subtilis involved in branched-chain amino acid transport”. Journal of Bacteriology, vol. 179, No. 17, p. 5448-5457, 1997.
Schrumpf et al., “Isolation and prominent characteristics of an L-lysine hyperproducing strain of Corynebacterum glutamicum.”, Applied Microbiology and Biotechnology, vol. 37, p. 566-571, 1992.
Patek et al., “Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation of lysine synthesis.”, Applied and Environmental Microbiology, vol. 60, No. 1, p. 133-140, 1994.
Changfeng et al., “Comparison of the sensitivities of two Escherichia coli genes to in vivo variation of Lrp concentration.” Journal of Bacteriology, Feb. 1998. pp. 655-659.
Calvo et al., “The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli,” Microbiological Reviews, vol. 58, Nr.3, 1994, pp. 466-490.
Database EMBL, Accession Y10417, Apr. 1, 1997, Hay N.A. et al., XP002159022.
Database EMBL, Accession P37424, Oct. 1, 1994, Freidberg et al., XP002159024.

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