Nucleotide sequence comprising the genome of hepatitis B virus,

Details Nucleotide sequence comprising the genome of hepatitis B virus, Nucleotide sequence comprising the genome of hepatitis B virus,

1995-01-09

2000-08-01

Scheiner, Laurie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 234, 536 253, 435 693, 4351723, 4241841, 4241851, 4241891, 4242271, A61K 3929

Patent

active

060968796

ABSTRACT:
A process produces DNA corresponding to that of the DNA of the virus of B hepatitis. It comprises cloning in bacteria the latter DNA, previously repaired by means of the corresponding precursor nucleotides in the presence of a polymerase. Vectors contain the cloned DNA in their genomes. The cloned DNA is useful as a probe for detecting the presence of the virus of B hepatitis in biological samples, particularly blood or plasma. Its expression in bacteria provides a hybrid protein containing a protein fragment having vaccinating properties against hepatitis B. Nucleic acid of reduced size and a vector containing the nucleotide sequence of which DNA codes an immunogenic peptide sequence capable of inducing the generation of antibodies to the virus of viral hepatitis B. It comprises totally or partly the sequence of nucleotides represented in FIG. 9A. Application to the production by cloning in a bacterium of an immunogenic protein immunizing against hepatitis B, or application to the obtention of probes for the diagnosis of the presence of Dane particles in the serum.

REFERENCES:
patent: Re34705 (1994-08-01), Galibert et al.
patent: 4415491 (1983-11-01), Vyas et al.
patent: 4483793 (1984-11-01), Vyas et al.
patent: 4596792 (1986-06-01), Vyas et al.
patent: 5017558 (1991-05-01), Vyas et al.
Burrell et al., Nature, 279:43-47 (1979).
Sninsky et al., Nature, 279:346-348 (1979).
Galibert et al., Nature, 281:646-650 (1979).
Valenzuela et al., Nature 280:815-819 (1979).
Summers et al, Proc. Nat. Acad. Sci. USA, vol. 72, No. 11, pp. 4597-4601, Genome of Hepatitis B Virus: Restriction Enzyme Cleavage and Structure of DNA Extracted From Dane Particles, Nov. 1975.

Affiliated with

Also associated with

Rating

Nucleotide sequence comprising the genome of hepatitis B virus, does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleotide sequence comprising the genome of hepatitis B virus, , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleotide sequence comprising the genome of hepatitis B virus, will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-665239