Nucleotide probes and methods for determining TaqI polymorphisms

Details Nucleotide probes and methods for determining TaqI polymorphisms Nucleotide probes and methods for determining TaqI polymorphisms

1994-01-26

1996-09-10

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

935 77, 935 78, C12Q 168

Patent

active

055545092

ABSTRACT:
A polynucleotide probe capable of hybridizing to human genomic DNA between the TaqI sites immediately 5' and 3' of the polymorphic leader TaqI site of the human Apo(a) gene, said human genomic DNA being detectable by PCR amplification of the Apo(a) gene using the 5' and 3' primers:

REFERENCES:
Genomics, vol. 17, No. 1, Jul. 1993, H. G. Kraft, et al., "Demonstration of Physical Linkage Between The Promoter Region And The Polymorphic Kringle IV Domain In The Apo(a) Gene by Pulsed-Field Gel Electrophoresis", pp. 260-262.
Human Molecular Genetics, vol. 2, No. 7, Jul. 1993, Carolin Lackner, et al., "Molecular Definition of the Extreme Size Polymorphism in Apolipoprotein(a)", pp. 933-940.
Chemical Abstracts, vol. 114, No. 23, Jun. 10, 1991, AN 227059x, Hideaki Itoh, "Restriction Fragment Length Polymorphisms in Apolipoprotein Genes in Coronary Heart Disease and Diabetes Mellitus", p. 659.
The Journal of Clinical Investigation, vol. 85, No. 6, Jun. 1990, Angelo M. Scanu, et al., "Lipoprotein (a)", pp. 1709-1715.
M. D. Biggin, et al., "Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination", Proc. Natl. Acad. Sci (USA) vol. 80, Jul. 1983, pp. 3963-3965.
J. W. McLean, et al, "cDNA sequence of human apolipoprotein(a) is homologous to plasminogen", Nature, vol. 300, Nov. 1987, pp. 132-137.
Lackner et al. J. Clin. Invest. 87: 2153-2161 (Jun. 1991).

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