Nucleotide or nucleoside photoaffinity compound modified antibod

Details Nucleotide or nucleoside photoaffinity compound modified antibod Nucleotide or nucleoside photoaffinity compound modified antibod

1996-07-23

1998-09-01

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 79, 435 75, 5303911, 5303913, 5303915, 5303917, 5303919, G01N 3353, C07K 1600, C12P 2100, C12Q 168

Patent

active

058009914

ABSTRACT:
Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of different antibody molecules. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These nucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.

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