Nucleotide molecule encoding a specific Onchocerca volvulus anti

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 4, 435 71, 435 722, 435 691, 435 711, 435 712, 4351723, 4352523, 4353201, 530350, 536 231, 536 234, 536 235, 536 237, A61K 39002, C07K 1508, C12N 1530

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054160090

ABSTRACT:
The present invention relates to a DNA segment encoding an Onchocerca volvulus antigen: a specific and early marker of onchocerciasis infection. The nvention further relates to recombinant molecules containing such a segment and to methods of utilizing same to produce the Onchocerca volvulus antigen. The invention also relates to the antigen itself. The invention further relates to methods of diagnosing Onchocerciasis infection.

REFERENCES:
Hugh R. Taylor, et al., "Impact of Mass Treatment of Onchocerciasis with Ivermetcin on the Transmission of Infection", Science 250:116-118 (1990).
Niklaus Weiss et al., "Evaluation of a Specific Enzyme Immunoassay for Onchocerciasis Using a Low Molecular Weight Antigen Fraction of Onchocerca Volvulus", Am. J. Trop. Med. Hyg. No. 3, 40:261-267 (1989).
Richard Lucius, et al., "Molecular Cloning of an Immunodominant Antigen of Onchocerca Volvulus", J. Exp. Med. 168:1199-1204 (1988).
Hugh R. Taylor et al., "Invermectin Prophylaxis Against Experimental Onchocerca Volvulus Infection in Chimpanzees" Am. J. Trop. Med. Hyg. No. 1, 39:86-90 (1988).
Thomas R. Unnasch et al., "Isolation and Characterization of Expression cDNA Clones Encoding Antigens of Onchocerca Volvulus Infective Larvae", J. Clin. Invest. 82:262-269 (Jul. 1988).
John E. Donelson et al., "Construction of Onchocerca Volvulus cDNA libraries and Partial Characterization of the cDNA for a Major Antigen", Mol. Biochem. Parasitol., 31:241-250 (1988).
Zully Cabrera et al., "Identification of Antigens of Onchocerca Volvulus and Onchocerca Gibsoni for Diagnostic Use", Mol. Biochem. Parasitol., 20:225-231 (1986).
Niklaus Weiss et al., "Humoral Immune Responses in Human Onchocerciasis: Detection of Serum Antibodies in Early Infections", Ciba Found. Symp. 27:180-188 (1987).
World Health Organization, Technical Report Series (WHO Expert Committee on Onchocerciasis, 3rd Report), No. 752, WHO, Geneva (1987).
M. A. Aziz, "Ivermectin vs. Onchocerciasis", Parasitology Today, 2(9):233-235 (Sep. 1986).
J. Walsh, "River Blindness: A Gamble Pays Off", Science 232:922-925 (May 23, 1986).
E. Lobos et al., "Identification of Non-crossreacting Antigens of Onchocerca Volvulus With Lymphatic Filariasis Serum Pools", Parasitology, 93:389-399 (1986).
Marc Karam et al., "Seroepidemiological Investigations of Onchoerciasis in a Hyperendemic Area of West Africa", Am. J. Trop. Med. Hyg., 34(5):907-917 (1985).
N. A. Kaushal et al., "Excretory-secretory and Somatic Antigens in the Diagnosis of Human Filariasis", Clin. Exp. Immunol., 56:567-576 (1984).
H. Schulz-Key et al., "Isolation of Living Adult Onchocerca Volvulus From Nodules", Tropenmed. Parasitol., 28:428-430 (1977).
Pierre Ambroise-Thomas, "Immunological Diagnosis of Human Filariasis: Present Possibilities, Difficulties and Limitations", Acta Trop. 31:108-128 (1974).
Gallin, M. Y. et al. (1987) J. Inf. Dis. 160:521-529.
Lobos E. et al. (1990) Med. Biochem. Parasitol. 39:135-146.
Dinman, J. D. et al. (1990) Exp. Parasitol. 71:176-188 (abstract only provided).
Corina, K. F. et al. (1990) J. Immunol. 145:1551-1556.
Maiha, C. V. et al. (1988) Gene 74:365-373.
Young, R. A. et al. (1983) Proc. Natl. Acad. Sci. USA 80:1194-1198.

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