Nucleotide lipid ester derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S026500, C536S026600

Reexamination Certificate

active

07419965

ABSTRACT:
The subject of the present invention is specific lipidesters of halogenated nucleotides of the following formulawherein R1, R2, R3, X and Y are defined as described herein and salts thereof, said compounds have anti-cancer properties; pharmaceutical compositions containing the compounds, a method of synthesizing the compounds, and a method of using the compounds for treating malignant tumors.

REFERENCES:
patent: 5512671 (1996-04-01), Piantadosi et al.
patent: 0 219 829 (1987-04-01), None
patent: 0 350 287 (1990-01-01), None
patent: WO 92/03462 (1992-03-01), None
patent: WO 96/15234 (1996-05-01), None
Montgomery et al., “Synthesis and Biologic Activity of 2′-Fluoro-2-Halo Derivatives of 9-Beta-D-Arabinofuranosyladenine”, Journal of Medicinal Chemistry, vol. 35, No. 2, 1992, pp. 397-401.
Zaitseva et al., “Convergent syntheses and cytostatic properties of 2-chloro-2′-deoxy-2, fluoroadenosine and its N(7)-isomer”, Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 24, Dec. 21, 1995, pp. 2999-3002.
Maruyama et al., “Synthesis and anti-HIV activity of 2-substituted 2′-deoxy-2′-fluoroadenosines”, Nucleosides and Nucleotides, vol. 13, No. 6-7, 1994, pp. 1219-1230.
Wright et al., “Nucleosides. LX.1aFluorocarbohydrates. XXII.1bSynthesis of 2-Dexoy-2-fluoro-D-arabinose . . . ”, The Journal of Organic Chemistry, vol. 34, No. 9, Sep. 1969, pp. 2632-2636.
Bosies et al., “Synthesis of Thioether Phosphocholine Analogues”, Lipids, vol. 22, No. 11 (1987), pp. 947-951.
Meyer et al., “In Vitro Evaluation f Phosphocholine and Quaternary Ammonium Containing Lipids as Novel Anti-HIV Agents”, J. Med. Chem., 1991, vol. 34, pp. 1377-1383.
Hostetler et al., “Synthesis and Antiretroviral Activity of Phospholipid Analogs of Azidothymidine and Other Antiviral Nucleosides”, The Journal of Biological Chemistry, vol. 265, Apr. 15, 1990, No. 11, pp. 6112-6117.
Hong et al., “Nucleoside Conjugates. 11. Synthesis and Antitumor Activity of 1-β-D-Arabinofuranosylcytosine and Cytidine Conjugates of Thioether Lipids”, J. Med. Chem. 1990, 33, 1380-1386.
Shuto et al., “A Facile Enzymatic Synthesis of 5′-(3-sn-Phosphatidyl)nucleosides and Their Antileukemic Activities”, Chem. Pharm. Bull. vol. 36, (1) pp. 209-217, 1988.

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