Nucleotide and oligonucleotide prodrugs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C514S04400A, C514S048000, C514S052000, C536S022100, C536S026100

Reexamination Certificate

active

08076303

ABSTRACT:
The present invention discloses compounds of formula (I):which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of anti-HBV treatment. The invention also relates to methods of treating a HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

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patent: 6881831 (2005-04-01), Iyer et al.
patent: 7256179 (2007-08-01), Iyer et al.
patent: 98/07734 (1998-02-01), None
patent: WO98/07734 (1998-02-01), None
Iyer, Radhakrishnan P., et al., “Nucleotide analogs as novel anti-hepatitis B virus agents,” Current Opinion in Pharmacol., 5: 520-528 (2005).
Iyer, Radhakrishnan P., et al., “Phosphorothioate Di- and Trinucleotides as a Novel Class of Anti-Hepatitis B Virus Agents,” Antimicrob. Agents and Chemotherapy, 48: 2199-2205 (2004).
Iyer, Radhakrishnan P., et al., “Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model,” Antimicrob. Agents and Chemotherapy, 48: 2318-2320 (2004).
Bundgaard, H., “Design of Bioreversible Drug Derivatives and the Utility of the Double Prodrug Concept,” in Bio-reversible carriers in drug design (Ch. 2). Theory and Application. Roche, E.B. Ed.; Pergamon Press: New York, 1987; pp. 13-94.
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Papot, S., et al., “Design of Selectively Activated Anticancer Prodrugs: Elimination and Cyclization Strategies,” Curr. Med. Chem., 2: 155-185 (2002).
Hayat, S., et al., “An Alternative Method for the Highly Selective Iodination of Alcohols Using a Csl/BF3.Et2O System,” Synth. Commun., 33(14): 2531-2540 (2003).
Fernández, I., et al., “A Simple Convenient Procedure for the Synthesis of Formate Esters and Alkyl Iodides from Alcohols Using the System Thionyl Chloride-Dimethylformamide-Alkaline Iodide,” Synlett, 489-490 (1993).

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