Nucleotide and amino acid sequences of C4-2, a tumor suppressor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435 723, 4353201, 530350, C07H 2104, G01N 33574, C12N 1500, C07K 100

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059902949

ABSTRACT:
The present invention relates to the discovery, identification and characterization of a novel tumor suppressor gene C4-2. The invention encompasses nucleotide sequences of the C4-2 gene and amino acid sequences of its encoded protein product(s), as well as derivatives and analogs thereof. The invention also encompasses the production of C4-2 proteins and antibodies. The invention further encompasses therapeutic compositions and methods of diagnosis and therapy.

REFERENCES:
Benton and Davis, 1977, "Screening .lambda.gt Recombinant Clones by Hybridization to Single Plaques in situ", Science 196:180-182.
Bogler et al., 1995, "The p53 Gene and Its Role in Human Brain Tumors", GLIA 15:308-327.
Boynton and Whitfield, 1983, "The Role of Cyclic AMP in Cell Proliferation: A Critical Assessment of the Evidence", Adv. Cyclo. Nucleo. Res. 15:193-294.
Brene et al., 1994, "Expression of m2RNAs Encoding ARPP-16/19, ARPP-21, and DARPP-32 in Human Brain Tissue", J. Neuroscience 14:985-998.
Chen et al., 1995, "Connexin43 Reverses the Phenotype of Transformed Cells and Alters Their Expression of Cyclin/Cyclin-Dependent Kinases", Cell Growth Differ. 6:681-690.
Faillot et al., 1996, "A Phase I Study of an Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for the Treatment of Malignant Gliomas", Neurosurgery 39:478-483.
Furnari et al., 1995, "Genetics and Malignant Progression of Human Brain Tumours", Cancer Surveys 25:223-275.
Grunstein and Hogness, 1975, "Colony Hybridization: A Method for the Isolation of Cloned DNAs that Contain a Specific Gene", Proc. Natl. Acad. Sci. USA 72:3961-3965.
Hadman et al., 1995, "Modifications to the Differential Display Technique Reduce Background and Increase Sensitivity", Anal. Chem. 226:383-386.
Horiuchi et al., 1990, "Purification and cDNA Cloning of ARPP-16, a cAMP-Regulated Phosphoprotein Enriched in Basal Ganglia, and of Related Phosphoprotein, ARPP-19", J. Biol. Chem. 265:9476-9484.
Ikonomov and Jacob, 1996, "Differential Display Protocol with Selected Primers that Preferentially Isolates mRNAs of Moderate-to Low-Abundance in a Microscopic System", Biotechniques 20:1030-1042.
Laws and Thapar, 1993, "Brain Tumors", CA Cancer J. Clin. 43:262-271.
Liang et al., 1992, "Differential Display and Cloning of Messenger RNAs from Human Breast Cancer versus Mammary Epithelial Cells", Cancer Res. 52:6966-6968.
Liang and Pardee, 1992, "Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction", Science 257:967-971.
Parker et al., 1996, "Cancer Statistics, 1996", CA Cancer J. Clin. 46:5-28.
Ponder, 1990, Inherited Predisposition to Cancer, Trends Genet. 6:213-218.
Sehgal et al., 1996, "Isolation of Differentially Expressed cDNAs During Ferret Tracheal Development: Application of Differential Display PCR", Exp. Lung Res. 22:419-434.
Shilo and Weinberg, 1981, "DNA Sequences Homologous to Vertebrate Oncogenes Are Conserved in Drosophila melanogaster", Proc. Natl. Acad. Sci. USA 78:6789-6792.
Weinberg, 1991, "Tumor Supressor Genes", Science 254:1138-1146.
Harada et al., 1996, "Molecular Genetic Investigation of the Neurofibromatosis Type 2 Tumor Suppressor Gene in Sporadic Meningioma", J. Neurosurg. 84:847-851.
Sehgal et al., 1997, "Characterization of C4-2 as a Tumor-Suppressor Gene in Human Brain Tumors", J. Surg. Oncol. 64:102-108.
Sehgal et al., 1997, "Cloning, Sequence and Developmental Expression Analysis of C4-2, a Potential Brain Tumor-Suppressor Gene", J. Surg. Oncol. 65:249-257.

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