Nucleotide and amino acid sequences, and assays and methods...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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11043824

ABSTRACT:
Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

REFERENCES:
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patent: WO 01/32927 (2001-05-01), None
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Sequence comparison.
PCT Written Opinion Of The International Searching Authority for PCT/IB2005/001306 (In English).
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Thin-filament-binding domains of cardiac and fast skeletal muscle troponin I isoforms as studied by epitope tagging, Toyota et al., Journal of Muscle Research and Cell Motility, 20:755-760, 1999 (in English).
Alu-Containing Exons are Alternatively Spliced, Sorek et al., Department of Zoology, pp. 1060-1067 (in English).
XP-002366938 BQ230791 standard, National Institutes of Health, Mammalian Gene Collection, Contact: Dr. Robert Strausberg (1 pg.) (in English).
PCT Preliminary Report on Patentability dated Aug. 3, 2006 for PCT Application No. PCT/IB2005/001306, In English.

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