Nucleotide analogues comprising a reporter moiety and a...

Details Nucleotide analogues comprising a reporter moiety and a... Nucleotide analogues comprising a reporter moiety and a...

2006-07-18

2006-07-18

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025320, C536S025310, C536S026600, C536S028600, C536S028400, C536S027220, C536S124000, C544S277000, C514S045000, C435S006120, C435S007920, C435S007940

Reexamination Certificate

active

07078499

ABSTRACT:
Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W is a phosphate group, B is a base, Y is a linker comprising an enzyme-cleavable group, R2is a reporter moiety, R3is selected from H or OH, Z and Z′ are selected from H, OH, or a group X—R1, wherein X is a linker comprising an enzyme-cleavable group and R1is a polymerase enzyme blocking group, provided that at least one of Z and Z′ is X—R1.

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