Nucleotide analogs for nucleic acid labeling and detection

Details Nucleotide analogs for nucleic acid labeling and detection Nucleotide analogs for nucleic acid labeling and detection

1984-11-08

1989-05-09

Brown, Johnnie R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 27, 536 28, 536 29, C12Q 168, C07H 1910, C07H 1920

Patent

active

048289795

ABSTRACT:
Nucleotide analogs, modified by the attachment at hydrogen bonding positions of linker groups, that is, the 6-position of adenine, 4-position of cytosine, and 2-position of guanine, are prepared. Such analogs, alone or with reporter groups attached, may be incorporated into DNA probes which effectively hybridize to target DNA.

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patent: 4460772 (1984-07-01), Benovic et al.
patent: 4707440 (1987-11-01), Stavrianopoulos
Murasugi et al., DNA, vol. 3, No. 3 (Jul. 1984), pp. 269-277.
Guilford et al., Chemical Scripta (Sweden) 1972, 2(4), pp. 165-170.

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