Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1995-12-29
1999-03-23
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544179, 544182, 544195, 514 79, 514 84, 514 86, C07D23922, C07F 902, A61K 31675
Patent
active
058861793
ABSTRACT:
Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
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Arimilli Murty N.
Bischofberger Norbert W.
Jones Robert J.
Lee William A.
Prisbe Ernest J.
Coleman Brenda
Gilead Sciences, Inc.
Muenchau Daryl D.
Shah Mukund J.
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