Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-09-17
1997-08-12
Wilson, James O.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2714, 536 2721, 536 276, 536 277, 536 278, 536 2781, 536 282, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, 544242, 544243, 544244, 544264, 544265, 544267, 544303, 544304, 544310, C07H 1906, C07H 1916, C07D23900, C07D47300
Patent
active
056567456
ABSTRACT:
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
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Arimilli Murty
Bischofberger Norbert
Jones Robert J.
Lin Kuei-Ying
Louie Michael
Gilead Sciences, Inc.
Muenchau Daryl D.
Wilson James O.
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