Nucleosidylphosphite-borane compounds and method of making the s

Details Nucleosidylphosphite-borane compounds and method of making the s Nucleosidylphosphite-borane compounds and method of making the s

1992-07-06

1993-11-09

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

558 72, 562 11, 435 915, C07H 1504, C12P 1934, A61K 3169, C07F 906

Patent

active

052604276

ABSTRACT:
Nucleosidyl phosphite-borane compounds of the formula: ##STR1## wherein: Nucleoside is a natural or synthetic nucleoside connected to the phosphorus atom via a hydroxyl oxygen; each X is independently selected from O and BHR.sub.3 R.sub.4 ;R.sub.1 is selected from H, alkyl, aryl, alkyaryl, monovalent metal ions, and ammonium cation; R.sub.2 is selected from OR.sub.1 and N(R.sub.5).sub.2, wherein R.sub.5 is independently selected from H, C.sub.1 -C.sub.10 linear or branched alkyl or aryl; R.sub.3 is selected from H, CN, COOH, carboxyl salts, COOR.sub.6 and CONHR.sub.6, wherein R.sub.6 is selected from H, C.sub.1 -C.sub.10 alkyl, alkylaryl and aryl; R.sub.4 is selected from H and C.sub.1 -C.sub.10 alky; and n is 1 to 2.

REFERENCES:
patent: 4209510 (1980-07-01), Spielvogel et al.
patent: 4312989 (1982-01-01), Spielvogel et al.
patent: 4368194 (1983-01-01), Spielvogel et al.
patent: 4587359 (1986-05-01), Spielvogel et al.
patent: 4647555 (1987-03-01), Spielvogel et al.
patent: 4709083 (1987-11-01), Spielvogel et al.
patent: 4855493 (1989-08-01), Spielvogel et al.
patent: 4963655 (1990-10-01), Kinder et al.
Sood et al. "Jour. Am. Chem. Soc." vol. 112, pp. 9000-9001 No. 24 Nov. 21, 1990.
Tomasz et al. "Angew. Chem. Int. Ed. Engl." 1992, vol. 31, No. 10 pp. 1373-1375 Oct. 1992.
Reetz, T., "Trialkyl Borine., A New Type of Phosphorous-Boron Compound," J. Am. Chem. Soc. 1960, 82, 5039-5042.
Sood, Anup, et al "Boron Analogues of Phosphonoacetates: Synthesis, Characterization and Antitumor Properties of Sodium Diethylphosphitecarboxyborane and Related Compounds", unpublished manuscript.
Spielvogel, Bernard F., et al., "From boron analogues of amino acids to borinated DNA: potential new pharmaceuticals and neutron capture agents," Pure and Appl. Chem., vol. 63, No. 3, pp. 415-418, '91.
Boron Containing Nucleic Acids. 2. Synthesis of Oligonucleoside Boranophosphates, J. Am. Chem. Soc. 1990, 112, 9000, and Commentary by Mark P. Wentland, Chemtracts-Organic Chemistry 4: 176-179 (1991) by both Sood, Anup.
Spievogel, B. F., et al, "Boron Containing Nucleic Acids," Progress in Neutron Capture Therapy for Cancer, edited by B. J. Allen, et al, Plenum Press, NY, 1992, pp. 211-213.

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