Nucleosides possessing blocked aliphatic amino groups

Details Nucleosides possessing blocked aliphatic amino groups Nucleosides possessing blocked aliphatic amino groups

1988-12-19

1991-05-14

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, 536 27, 536 28, 536 29, C07H 19073, C07H 1916, C07H 1910, C07H 1920

Patent

active

050157337

ABSTRACT:
The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieites may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

REFERENCES:
patent: 3906031 (1975-09-01), Carpino et al.
patent: 4373071 (1983-02-01), Itakura
patent: 4401796 (1983-08-01), Itakara
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4757141 (1988-07-01), Fung et al.
Chu et al., Nucl. Acids Research 11 (1983), 6513-29.
Langer et al., Prac. Natl. Acad. Sci. U.S.A. 78(11), 6633-7 (1981).
Draper et al., Biochemistry 19(1980), 1774-81.

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