Nucleosides and oligonucleotides having 2'-ether groups

Details Nucleosides and oligonucleotides having 2'-ether groups Nucleosides and oligonucleotides having 2'-ether groups

1995-06-02

1999-10-19

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 514 44, 536 231, 536 245, C07H 1900, A01N 4304, C12Q 168

Patent

active

059691166

ABSTRACT:
Compounds of the formula ##STR1## are described wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or a protecting group, or

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Jenny, T. et al. Nucleosides & Nucleotides, 11(6), 1257-1261 (1992).
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Iribarren et al., Proc. Natl. Acad. of Sci., 87:7747-7751 (1990).
Stein et al. "Antisense Oligonucleotides as Therapeutic Agents-Is the Bullet Really Magical?" Science, vol. 261, pp. 1004-1012, Aug. 1993.
Solomons "Organic Chemistry, Fifth Edition" John Wiley & Sons, Inc., pp. 431, 432, 699, 1992.

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