Nucleoside trichlorodimethylethyl phosphite esters

Details Nucleoside trichlorodimethylethyl phosphite esters Nucleoside trichlorodimethylethyl phosphite esters

1985-07-25

1988-11-22

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1910, C07H 1920, C07H 19207

Patent

active

047867248

ABSTRACT:
Novel trichlorodimethylethyl phosphite esters are utilized as intermediates in a new synthesis procedure for producing oligonucleotides. On completion of the synthesis the trichlorodimethylethyl protecting group can be cleaved by reaction with tributylphosphine or hexamethylphosphoramide.

REFERENCES:
patent: 4419509 (1983-12-01), Hsiung
patent: 4458066 (1984-07-01), Caruthers et al.
Letsinger et al., "Jour. Amer. Chem. Soc.", vol. 104, 1982, pp. 6805-6806.
Eckstein, "Chem. Abst.", vol. 64, 1966, p. 3662a.
Koester et al., "Chem. Abst.", vol. 94, 1981, p. 140092x.
Kellner et al., "Chem. Abst.", vol. 95, 1981, p. 98203c.

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