Nucleoside thiophosphoramidites

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 2672, 536 265, 536 268, 536 2671, 568 18, C07H 1910, C07H 1920, C07H 2100

Patent

active

052181030

ABSTRACT:
The present invention relates to new and useful nucleside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorothioamidate phosphoramidite compounds as well as the process whereby these compounds can be used for synthesizing new monoucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters and phosphorothioate internucleotide linkages.

REFERENCES:
patent: 3451997 (1969-06-01), Fujimoto et al.
patent: 3687808 (1972-08-01), Merigan, Jr. et al.
patent: 3846402 (1974-11-01), Erkstein et al.
patent: 3853844 (1974-12-01), Shuman et al.
patent: 4373071 (1983-02-01), Itakura
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4668777 (1987-05-01), Caruthers et al.
patent: 4728730 (1988-03-01), Frey et al.
patent: 4808708 (1989-02-01), Yoshida et al.
Matsukura et al. 1987, Proc. Natl. Acad. Sci. vol. 84, pp. 7706-7710.
Stec et al. 1984, J. Am. Chem. Soc. vol. 106, pp. 6077-6079.
Eckstein, F. 1970, J. Am. Chem. Soc. vol. 92, No. 15, pp. 4718-4723.
Froehler, B. C. 1986, Tetrahedron Letters, vol. 27, No. 46, pp. 5575-5578.
Stein et al. 1988, Nucleic Acids Res. vol. 16, No. 8, pp. 3208-3221.
Sekine et al. 1979, J. Organic Chem. vol. 44, No. 13, pp. 2325-2326.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleoside thiophosphoramidites does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleoside thiophosphoramidites, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleoside thiophosphoramidites will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1935114

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.