Nucleoside process

Details Nucleoside process Nucleoside process

1983-11-18

1986-11-25

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536118, 536119, C07H 1500, C07H 1506

Patent

active

046250204

ABSTRACT:
Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.

REFERENCES:
patent: 4211773 (1980-07-01), Lopez et al.
Ness and Fletcher, J. Amer. Chem. Soc. 78, 4710-14 (1956).
Ibid., 76, 1663-6 (1954).
Reichman et al., A Practical Synthesis of 2-Deoxy-2-Fluoro-D-Arabinofuranose Derivatives, Carbohydrate Research 42, 233 (1975).
Ritzmann, Nucleosides LXXXIX, Synthesis of 1-(2-Chloro-2-Deoxy-(.alpha. and .beta.)-D-Arabinofuranosyl)Cytosines, Carbohydrate Research 39, 227 (1975).
Stevens et al., The Proton Magnetic Resonance of Pentofuranose Derivatives, J. Org. Chem. 33(5), 1799-1805 (1968).
Chavis et al., Synthesis of 1,3,5-Tri-O-Acyl-.alpha.-.+-.-D-Ribofuranoses Substituted at Position 2, Chem. Abstracts 89: 180298x (1978).

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