Nucleoside phosphoramidates and nucleoside phosphoramidases

Details Nucleoside phosphoramidates and nucleoside phosphoramidases Nucleoside phosphoramidates and nucleoside phosphoramidases

2007-05-15

2007-05-15

Fredman, Jeffrey (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C422S173000, C435S007400, C435S007600, C435S007720, C435S183000, C530S350000, C536S023200, C536S023400

Reexamination Certificate

active

11174121

ABSTRACT:
The invention provides isolated nucleic acid sequences encoding polypeptides having nucleoside phosphoramidase activity, and methods of screening for nucleoside phosphoramidate compounds that are cleaved by a phosphoramidase or for phosphoramidases that are able to cleave phosphoramidate compounds. The invention also provides methods of delivering a nucleoside monophosphate.

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