Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1986-04-15
1989-01-10
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 28, 536 29, 544276, C07H 1910, C07H 1920, C07D47300
Patent
active
047974796
ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are long-chain fatty acid residue, and Ns is nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, 5-fluoro-2'-deoxyuridine-5'-yl-, bredinin-5'-yl, tubercidine-5'-yl-, neplanocin A-6'-yl-, 5-fluorocytidine-5'-yl-, arabinosylcytosine-5'-yl, arabinocyl-5-fluorocytosine-5'-yl-, arabinosyladenine-5'-yl- and arabinosylthymine-5 '-yl-, and pharmacologically acceptable salts thereof, having antitumor activity.
REFERENCES:
patent: 4291024 (1987-09-01), Turcotte
Nucleosides, Nucleotides and Their Biological Application, 41st Event of FECS, MacCoss et al., pp. 46-47, Feb. 1981.
Ramirez et al., the Chemical Abstracts, 97 3933d, 1982.
Ramirez et al., the Chemical Abstracts, 97 145213j, (1982).
Ryu et al., J. Med. Chem., 25, 1322-1329, (1982).
"Cytotoxic Liponucleotide Analogs, I. Chemical Synthesis of CDP-Diacylglycerol Analogs Containing the Cytosine Arabinoside Moiety", Biochimica et Biophysica Acta., 619 (1980) J. G. Turcotte et al., pp. 604-618.
"Cytotoxic Liponucleotide Analogs, II. Antitumor Activity of CDP-Diacylglycerol Analogs Containing the Cytosine Arabinoside Moiety", Biochimica et Biophysica Acta., 619 (1980), J. G. Turcotte et al., pp. 619-631.
"Phospholipid-Nucleoside Conjugates, 3. Syntheses and Preliminary Biological Evaluation . . .", J. Med. Chem., vol. 25, 1982, by Eung K. Ryu et al., pp. 1322-1329.
Fukukawa Kiyofumi
Ito Hiromichi
Sakakibara Hideo
Shuto Satoshi
Tsujino Masatoshi
Griffin Ronald W.
Tou Jenny
Toyo Jozo Kabushiki Kaisha
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