Nucleoside phosphate therapy for viral infection

Details Nucleoside phosphate therapy for viral infection Nucleoside phosphate therapy for viral infection

1997-12-16

2000-01-18

Wilson, James O.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424 7802, 424 7807, 424405, 514262, 514265, 514266, 514357, 514931, 514934, 514969, 546331, A61K 970, A61K 3174, A61K 3152, A01N 4390

Patent

active

060155736

ABSTRACT:
Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Also disclosed are methods for using the topical compositions in treatment of herpes disease.

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Prisbe, E.J., et al. (1986) Synthesis and antiherpes virus activity of phosphate and phosphonate derivatives of 9-[(1,3-dihydroxy-2-propoxy) methyl]) guanine J. Med. Chem. 29:671-675.
Darby, G. et al. (1980) Sensitivity of viruses to phosphorylated 9-(2-hydroxyethoxymethyl) guanine revealed in TK-transformed cells J. gen. Virol. 48:451-454.

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