Nucleoside Phosphatase

Details Nucleoside Phosphatase Nucleoside Phosphatase

2007-09-04

2007-09-04

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S196000, C435S252300, C435S325000, C435S320100, C536S023200

Reexamination Certificate

active

10160501

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 39228, 21956, 25856, 22244, 8701, 32263, 50250, 55158, 47765, 62088, 50566, and 48118 nucleic acid molecules, which encode novel GTPase activating molecules, cadherin molecules, and ankyrin containing family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 39228, 21956, 25856, 22244, 8701, 32263, 50250, 55158, 47765, 62088, 50566, and 48118 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 39228, 21956, 25856, 22244, 8701, 32263, 50250, 55158, 47765, 62088, 50566, or 48118 gene has been introduced or disrupted. The invention still further provides isolated 39228, 21956, 25856, 22244, 8701, 32263, 50250, 55158, 47765, 62088, 50566, and 48118 polypeptides, fusion polypeptides, antigenic peptides and anti-39228, 21956, 25856, 22244, 8701, 32263, 50250, 55158, 47765, 62088, 50566, and 48118 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 6004808 (1999-12-01), Negulescu et al.
patent: 2002/0147140 (2002-10-01), Rosen et al.
patent: WO 01/34629 (2001-05-01), None
patent: WO 01/70979 (2001-09-01), None
patent: WO 01/70979 (2001-09-01), None
Shi, J-D., et al. (2001) J. Biol. Chem. 276(20), 17474-17478.
Blast results and background information of 62088 SEQ ID No. 1 of 10/160501 versus cDNA encoding musculoskeletal system antigens #1497 and #1508 from U.S. 2002/0147140 A1. This result is also found from sequences in other applications in this patent family.
Simpson, A.J.G., “PM1-HT0422-090100-004-h10 HT0422 Homo sapiens cDNA, mRNA sequence,” Mar 17, 2000, (sequence) EMBL [online], Hinxton, Cambridge, UK: European Bioinformatics Institute [retrieved on Nov. 24, 2004] Retrieved from internet: URL: http://srs.ebi.ac.uk. EMBL Accession No. AW580249.
Wray, P., “Human DNA sequence from clone RP11-483F11 on chromosome 10, complete sequence,” Mar. 4, 2003 (sequence), GenBank [online] Bethesda, MD, USA: [retrieved on Nov. 24, 2004] National Center for Biotechnology Information. Retrieved from the internet: URL: http://www.nchi.nlm.nih.gov. GenBank Accession No. AL133353.
Wang, C., et al., “Homo sapiens lysosomal apyrase-like protein 1 (LALP1) mRNA, complete cds,” May 14, 2001 (sequence), GenBank [online] Bethesda, MD, USA: [retrieved on Nov. 24, 2004] National Center for Biotechnology Information. Retrieved from the internet: URL: http://www.ncbi.nlm.nih.gov. GenBank Accession No. AF269255.

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