Nucleoside hydrogen phosphonodithioate diesters and activated ph

Details Nucleoside hydrogen phosphonodithioate diesters and activated ph Nucleoside hydrogen phosphonodithioate diesters and activated ph

1995-02-21

1996-10-15

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 267, 536 2674, 536 268, 536 269, C07H 1906, C07H 1916

Patent

active

055655556

ABSTRACT:
Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses, A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.

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