Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1981-07-20
1983-11-29
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 23, 2603971, A61K 3170, C07H 1700
Patent
active
044180594
ABSTRACT:
A composition comprising a nucleosidic anti-tumor agent esterified with a carboxylic acid-containing steroid is described. These steroid ester derivatives of, for example, a deoxyuridine compound provide enhanced anti-tumor effects in chemotherapy as compared to the corresponding nucleosides alone.
REFERENCES:
patent: 3282921 (1966-11-01), Verheyden et al.
patent: 3856777 (1974-12-01), Ishido et al.
patent: 4211773 (1980-07-01), Lopez et al.
Nishizawa et al., "Biochemical Pharmacology", vol. 14, (1965), pp. 1606-1619.
Montefiore Medical Center
Roberts Elbert L.
The Albert Einstein College of Medicine at Yeshiva University
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