Nucleoside derivatives as inhibitors of RNA-dependent RNA...

Details Nucleoside derivatives as inhibitors of RNA-dependent RNA... Nucleoside derivatives as inhibitors of RNA-dependent RNA...

2006-09-12

2006-09-12

Price, Elvis O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S043000, C514S045000, C514S042000, C514S050000, C514S052000, C514S046000, C536S028400, C536S028500, C536S026120

Reexamination Certificate

active

07105499

ABSTRACT:
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.

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