Nucleoside derivatives and therapeutic use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S042000, C514S049000, C514S050000, C514S256000, C514S269000, C536S018700, C536S022100, C536S028100, C544S242000

Reexamination Certificate

active

07405214

ABSTRACT:
The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.

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Hronowski et al: “Synthesis of cyclopentane analogs of 5-fluorouracil nucleosides” Canadian Journal of Chemistry, National Research Council. Ottawa, CA, vol. 70, No. 4, 1992, pp. 1162-1169.
Jeong Lak Shin et al: “Design, Synthesis, and Biological Evaluation of Fluoroneplanocin A as the Novel Mechanism-Based Inhibitor of S-Adenosylhomocysteine Hydrolase.” Journal of Medicinal Chemistry. Jan. 16, 2003, vol. 46, No. 2, pp. 201-203.

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