Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-29
2005-03-29
Riley, Jezia (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S025300
Reexamination Certificate
active
06872809
ABSTRACT:
Novel nucleoside derivatives represented by the following general formula (1):wherein X is(are) the same or different and each represents a pyrimidine or purine base or a derivative thereof, Y and Y′ are the same or different and each represents at least one amino acid or amino acid derivative selected from the group consisting of serine, threonine, ornithine, aspartic acid, glutamic acid, lysine, arginine, cysteine, methionine, δ-hydroxylysine, N-aminoethylglycine, N-aminoethylserine, N-aminoethyllysine, N-aminoethylornithine, N-aminoethylaspartic acid, N-aminoethylglutamic acid, homoglutamic acid, β-thiocarbonylaspartic acid, γ-thiocarbonylglutamic acid, and δ-thiocarbonylhomoglutamic acid, R1represents a hydrogen atom or a hydroxyl group, A represents a single bond or a carbonyl or thiocarbonyl group, 1 is an integer of 0 to 5, and n is an integer of 1 to 100.
REFERENCES:
Takehiko Wada, et al., “Peptide Ribonucleic Acids (PRNA). 2. A Novel Strategy for Active Control of DNA Recognition through Borate Ester Formation,” Journal of the American Chemical Society, 2000, vol. 122, No. 29, pp. 6900-6910.
Takehiko Wada, et al., “Conformational and Orientational Switching of Uridine Derivatives by Borates,” Chemistry Letters 1998, pp. 1025-1026.
Takehiko Wada, et al., “Synthesis and properties of oligolysine and oligoglutamic acid derivatives containing nucleosides,” Nucleic Acids Symposium Series No. 29, pp. 79-80, 1993.
Takehiko Wada, et al., “Synthesis and properties of polyamide derivatives containing nucleosides,” Nucleic Acids Symposium Series No. 35, pp. 97-98, 1996.
Takehiko Wada, et al., “Synthesis and properties of oligo-ω-amino acids derivatives containing nucleosides,” Nucleic Acids Symposium Series No. 34, pp. 189-190, 1995.
Hirofumi Sato, et al., “Synthesis and conformation control of peptide ribonucleic acid containing 5′-amino-5′-deoxyribopurinenucleosides,” Nucleic Acids Symposium Series No. 44, pp. 211-212, 2000.
Jeewoo Lee, et al., “Methionyl Adenylate Analogues as Inhibitors of Methionyl-tRNA Synthetase,” Bioorganic & Medicinal Chemistry Letters (1999), 9(10), pp. 1365-1370.
Kiyoshi Isono, et al., “Polyoxin Analogs. I. Synthesis of Aminoacyl Derivatives of 5′-Amino-5′-deoxyuridine,” Chemical & Pharmaceutical Bulletin (1971), 19(3), pp. 505-512.
Rosario Herranz, et al., “Synthesis of 5′-N-(α-amino-β-mercaptoacyl)=amino-5′-deoxynucleosides as potential antiviral compounds,” Chemical Abstracts, vol. 116, No. 1, Jan. 6, 1992.
Chi-Deu Chang; et al., “Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5′-thioether linkage,” Journal of Medicinal Chemistry (1976), 19(5), pp. 684-691.
Inoue Yoshihisa
Wada Takehiko
Japan Science and Technology Corporation
Knobbe Martens Olson & Bear LLP
Riley Jezia
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