Nucleoside derivatives

Details Nucleoside derivatives Nucleoside derivatives

1993-05-27

1996-09-03

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2532, 536 268, 536 2853, 536 2854, C07H 1906

Patent

active

055525407

ABSTRACT:
A nucleoside derivative of formula (1), characterized in that: Y is H or OH or a protected hydroxy group; X is H, a phosphonate group or a phosphoramidite group of formula (II), where R.sup.1 and R.sup.2 are the same or different, and are selected from alkyl and substituted alkyl, which may be branched or unbranched; and Q is a phosphate protecting group; Z is H, a phosphate or triphosphate group or hydroxy protecting group; X' is a C.sub.1-15 alkyl group which may be branched or unbranched; R is an amino protecting group or a fluorophore, or other non-radioactive detectable marker; or the group Y'NHA, where Y' is an alkyl (C.sub.1-40) carbonyl group which may be branched or unbranched, and A is an amino protecting group or a fluorophore or other non-radioactive detectable marker. Methods for the synthesis and sequencing of polynucleotides utilizing compounds of formula (I).

REFERENCES:
patent: 4711955 (1987-12-01), Ward et al.
patent: 5047519 (1991-09-01), Hobbs, Jr. et al.
Langer et al., Proc. Natl. Acad. Sci. USA, vol. 78, No. 11 pp. 6633-6637, Nov. 1981.
Robins et al., Journal of Organic Chem., vol. 48, pp. 1854-1862, 1983.

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