Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-02-24
1995-04-25
Parr, Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4351723, 4352401, C07H 2104, C12N 1563, C12N 510
Patent
active
054100313
ABSTRACT:
The complete cDNA sequence encoding the amino acid sequence corresponding to mammalian Na.sup.+
ucleoside cotransporter protein (SNST) is disclosed. Methods for obtaining the gene encoding SNST and for obtaining recombinantly produced SNST are described. Antibodies, an inhibitor of nucleoside transport by SNST, and methods for detecting other inhibitors are also described. Methods for inhibiting uptake of nucleosides by SNST using the compositions of the invention are also included.
REFERENCES:
Williams, T. C., and S. M. Jarvis. Multiple Sodium-dependent nucleoside tsport systems in bovine renal . . . Biochem J. (1991) 274:27-33.
Jarvis, S. M. and D. A. Griffith. Expression of the rabbit intestinal N2 Na.sup.+
ucleoside transporter in Xenopus laevis oocytes. Biochem J. (1991) 278:605-607.
Peerce and Wright, "Conformational Changes in the Intestinal Brush Border Sodium-Glucose Cotransporter Labeled with Fluorescein Isothiocyanate", Proc. Natl. Acad. Sci. 81:2223-2226 (1984).
Wright and Peerce, "Identification and Conformational Changes of the Intestinal Proline Carrier", J. Biol. Chem. 259:14993-14996 (1984).
Radian et al., "Purification and Identification of the Functional Sodium- and Chloride-coupled .gamma.-Aminobutyric Acid Transport Glycoprotein from Rat Brain", J. Biol. Chem. 261:15437-15441 (1986).
Peerce and Wright, "Sodium-induced Conformational Changes in the Glucose Transporter of Intestinal Brush Borders", J. Biol. Chem. 259-14105-14112 (1984).
Peerce and Wright, "Evidence for Tyrosyl Residues at the Na.sup.+ Site on the Intestinal Na.sup.+ /Glucose Cotransporter", J. Biol. Chem. 260:6026-6031 (1985).
Peerce and Wright, "Distance Between Substrate Sites on the Na-glucose Cotransporter by Fluorescence Energy Transfer", Proc. Natl. Acad. Sci. 83:8092-8096 (1986).
Peerce and Wright, "Examination of the Na.sup.+ -Induced Conformational Change of the Intestinal Brush Border Sodium/Glucose Symporter Using Fluorescent Probes", Biochem. 26:4272-4279 (1987).
Hediger et al., "Expression Cloning and cDNA Sequencing of the Na.sup.+ /Glucose Co-Transporter", Nature 330:379-381 (1987).
Coady et al., "Sequence Homologies Among Intestinal and Renal Na.sup.+ /Glucose Cotransporter", Am. J. Physiol. 259:C605-C610 (1990).
Hediger et al., "Expression of Size-Selected mRNA Encoding the Intestinal Na/Glucose Cotransporter in Xenopus laevis Oocytes", Proc. Natl. Acad. Sci. 86:2634-2637 (1987).
Ohta et al., "Regulation of Glucose Transporters in LLC-PK.sub.1 Cells: Effects of D-Glucose and Monosaccharides", Mol. Cell. Biol. 10:6491-6499 (1990).
Nakao et al., "Nucleotide Sequence of putP, the Proline Carrier Gene of Escherichia coli K12", Mol. Gen. Genet. 208:70-75 (1987).
Jackowski and Alix, "Cloning, Sequence, and Expression of the Pantothenate Permease (pan F) Gene of Escherichia coli", Bacteriol. 172:3843-3848 (1990).
Turk et al., "Gluclose/Galactose Malabsorption Caused by a Defect in the Na.sup.+ /Glucose Cotransporter", Nature 350:354-356 (1991).
Belardinelli et al., "The Cardiac Effects of Adenosine", Prog. Cardiovasc. Diseases 32:73-97 (1989).
Yarchoan and Border, "Development of Antiretroviral Therapy for the Acquired Immunodeficiency Syndrome and Related Disorders", New Eng. J. Med. 316:557-564 (1987).
Newey et al., "The Effect of Some Analogues of Phlorrhizin on Intestinal Hexose and Fluid Transfer", J. Physiol. 169:229-236 (1963).
Diedrich, "Photoaffinity-Labeling Analogs of Phlorizin and Phloretin: Synthesis and Effects on Cell Membranes", Methods in Enzymology 191:755-780 (1990).
Plagemann et al., "Nuceloside and Nucleobase Transport in Animal Cells", Biochim. et Biophys. Acta 947:405-443 (1988).
Diedrich, "The Comparative Effects of Some Phlorizin Analogs on the Renal Reabsorption of Glucose", Biochim. et Biophys. Acta 71:688-700 (1963).
Diedrich, "Competitive Inhibition of Intestinal Glucose Transport by Phlorizin Analogs", Arch. Biochem. Biophys. 117:248-256 (1966).
Lin et al., "Synthesis of Phlorizin Derivatives and Their Inhibitory Effect on the Renal Sodium/D-Glucose Cotransport System", Biochim. et Biophys. Acta 693:379-388 (1982).
Kozak "Comparison of Initiation of Protein Synthesis in Procaryotes, Eucaryotes, and Organelles", Microbiol. Revs. 47:1-45 (1983).
Deguchi et al., "Nucleotide Sequence of gltS, the Na.sup.+ /Glutamate Symport Carrier Gene of Escherichia coli B", J. Biol. Chem. 265:21704-21708 (1990).
Hediger et al, "Biosynthesis of the Cloned Intestinal Na.sup.+ /Glucose Cotransporter", Biochim. et Biophys. Acta 1064:360-364 (1991).
Yamato, "Defective Cation-Coupling Mutants of Escherichia coli Na.sup.+ /Proline Symport Carrier", J. Biol. Chem. 265:2450-2455 (1990).
Lee et al., "Transport Characteristics of Renal Brush Border Na.sup.+ -and K.sup.+ -Dependent Uridine Carriers", Am. J. Physiol. 258:F1203-F1210 (1990).
Williams et al., "Characterization of Sodium-Dependent and Sodium-Independent Nucleoside Transport Systems in Rabbit Brust-Border and Basolateral Plasma-Membrane Vesticles from the Renal Outer Cortex", Biochem. 264:223-231 (1989).
Jarvis, "Characterization of Sodium-Dependent Nucleoside Transport in Rabbitt Intestinal Brush-Border Membrane Vesicles", Biochim. et Biophys. Acta 979:132-138 (1989).
Pajor Ana M.
Wright Ernest M.
Parr Margaret
Schreiber David
The Regents of the University of California Office of Technology
LandOfFree
Nucleoside cotransporter protein cDNA does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleoside cotransporter protein cDNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleoside cotransporter protein cDNA will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1568640