Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-10-12
1992-08-11
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 43, 536 11, 536 184, 536 187, 536 22, 536 23, 536 55, 536117, 536121, A61K 3100, C07H 1900
Patent
active
051378760
ABSTRACT:
The compound having the formula: ##STR1## has antiviral activity, specifically in the prevention or treatment of infection by retroviruses, including HIV, and immunosuppressive activity, either as a compound, pharmaceutically acceptable salt, or a pharmaceutical composition ingredient, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing or treating viral infections and modulating immune responses in vivo are also described.
REFERENCES:
patent: 4148888 (1979-04-01), Cantoni et al.
patent: 4309419 (1982-01-01), Wolberg et al.
patent: 4322411 (1982-03-01), Vinegar et al.
patent: 4690917 (1987-09-01), Knight et al.
J. P. Bader et al., 3-Deazaadenosine, and Inhibitor of Adenosylhamocysteine Hydrolase; Virology 89, 494 (1978).
A. J. Bodner et al., Antiviral Acitivty of 3-Deazaadenosine and . . . , Biochem, and Biophysic. Res. Comm., 98, 476 (1981).
P. A. Bonnet et al., N-Nitro and N-Nitroso derivatives in 5, 6, 7, 8 Tetrahydro . . . , J. Chem. Res., 1984, 28.
P. K. Chaing and G. L. Cantoni, Perturbation of Biochemical Transmethylations . . . , Biochem. Pharmac., 28, 1897 (1979).
P. K. Chaing et al., S-Adenosyl-L-Homocysteine Hydrolase: Analogues of S-Adenosyl . . . , Mol. Pharma., 13, 939 (1977).
M. F. DePompei and W. W. Paudler, The Synthesis and Some Chemical and Spectroscopic Properties, J. Heterocycl. Chem., 12, 861 (1975).
W. C. Luma and J. P. Springer, Novel Condensation of 2,3-Epoxybutanal . . . , J. Org. Chem., 46, 3735 (1981).
T. A. Krenitsky et al., Imidazo [4,5-c]pyridines (3-Deazapurines) and . . . , J. Med. Chem., 29, 138 (1986).
C. Levallois et al., Theophylline-like Properties of Xanthine Analogs, Biochem. Pharmaco., 33, 2253 (1984).
C. Sablayrolles et al., Synthesis of Imidazo [1,2-a] Pyrazine Derivatives . . . , J. Med. Chem., 27 206 (1984).
C. M. Stoltzfus and J. A. Montgomery, Selective Inhibition of Avian . . . , J. Virology 38, 173 (1981).
J. C. Teulade et al., C-3 Hydroxylation of some Imidazo [1,2-a]azines, J. Chem. Res. 1986, 202.
W. Trager et al., Plasmodium Falciparum: Antimalarial Activity . . . , Exp. Parasit., 50, 83 (1980).
B. Veroek et al., Hydrazinolysis of some asolopyrazines, Heterocycles, 4, 943 (1976).
W. E. Coyne, "Nonsteroidal Antiinflammataory Agents", Medicinal Chemistry (ed. A. Burger) p. 953 (Wiley-Interscience).
G. D. Diana et al., "Antiviral Agents", Annual Reports in Medicinal Chemistry, 24, p. 129 (1989).
Mitsuya et al., Japan Sci. Soc. Press Tokyo, Japan pp. 227-288 (1985).
Sandstshi et al., Review article in Drugs, 34, pp. 373-390 (1987).
Maccoss Malcolm
Meurer Laura C.
Tolman Richard L.
Brown Johnnie R.
Caruso Charles M.
Merck & Co. , Inc.
Meredith Roy D.
Muthard David A.
LandOfFree
Nucleoside antiviral and anti-inflammatory compounds and composi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleoside antiviral and anti-inflammatory compounds and composi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleoside antiviral and anti-inflammatory compounds and composi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-346406