Nucleoside and use thereof

Details Nucleoside and use thereof Nucleoside and use thereof

1988-09-16

1991-08-20

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1700, A61K 3176

Patent

active

050415433

ABSTRACT:
A compound 1-(3-azido-2,3-dideoxy-.beta.-D-erythro-pentofuranoxyl)-5-methyl-2(1H)-pyr imidinone and its use in a method of generating (forming, providing) 3'-azido-3'-deoxythymidine (zidovudine sometimes referred to as AZT) in the body of an animal (a mammal such as human) by systemically administering 1-(3-azido-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl)-5-methyl-2(1H)-pyr iminone to said animal (mammal such as a human) is disclosed. AZT is approved and used for treating HIV infections, e.g., AIDS and ARC in humans and also has activity against gram-negative bacteria in animals.

REFERENCES:
patent: 3208997 (1965-09-01), Iwai et al.
patent: 4395406 (1983-07-01), Gacek et al.
Imazawa et al., J. Org Chem. 43(15): 3045-3048, 1978.
Paper-J. Med. Chem. 1983, 26, pp. 1691-1996.
Paper-Chemical Abstracts, vol. 79, 1973, p. 136.

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