Nucleoside and oligonucleotide analogues

Details Nucleoside and oligonucleotide analogues Nucleoside and oligonucleotide analogues

2008-01-01

2008-01-01

Lewis, Patrick (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S022100, C536S026200, C536S025600, C536S027810, C536S027210, C536S027600, C536S028100, C514S043000, C514S04400A, C514S045000, C514S049000

Reexamination Certificate

active

10430705

ABSTRACT:
A probe for a gene or a primer for starting amplification comprising an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of the nucleoside units is a structure of the formula (2):wherein A represents a C1-C4alkylene group, and B is an unsubstituted purin-9-yl group, an unsubstituted 2-oxo-pyrimidin-1-yl-group, a substituted purin-9-yl-group or a substituted 2-oxo-pyrimidin-1-yl group. Also a method for preventing or treating a disease preventable or treatable by the antisense or antigene activity of an oligonucleotide by administering the oligonucleotide analogue.

REFERENCES:
patent: 3687808 (1972-08-01), Merigan, Jr. et al.
patent: 4689320 (1987-08-01), Kaji
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 5004810 (1991-04-01), Draper
patent: 5166195 (1992-11-01), Ecker
patent: 5194428 (1993-03-01), Agrawal et al.
patent: 5242906 (1993-09-01), Pagano et al.
patent: 5248670 (1993-09-01), Draper et al.
patent: 5442049 (1995-08-01), Anderson et al.
patent: 5457189 (1995-10-01), Crooke et al.
patent: 5514577 (1996-05-01), Draper et al.
patent: 5514788 (1996-05-01), Bennett et al.
patent: 5523389 (1996-06-01), Ecker et al.
patent: 5580767 (1996-12-01), Cowsert et al.
patent: 5582972 (1996-12-01), Lima et al.
patent: 5582986 (1996-12-01), Monia et al.
patent: 5591600 (1997-01-01), Ecker
patent: 5591623 (1997-01-01), Bennett et al.
patent: 5591720 (1997-01-01), Anderson et al.
patent: 5607923 (1997-03-01), Cook et al.
patent: 5620963 (1997-04-01), Cook et al.
patent: 5658891 (1997-08-01), Draper et al.
patent: 5661134 (1997-08-01), Cook et al.
patent: 5681747 (1997-10-01), Boggs et al.
patent: 5681944 (1997-10-01), Crooke et al.
patent: 5691461 (1997-11-01), Ecker et al.
patent: 5877309 (1999-03-01), McKay et al.
patent: 5955443 (1999-09-01), Bennett et al.
patent: 5985558 (1999-11-01), Dean et al.
patent: 6111094 (2000-08-01), Bennett et al.
patent: 6127533 (2000-10-01), Cook et al.
patent: 6268490 (2001-07-01), Imanishi
patent: 6670461 (2003-12-01), Wengel et al.
patent: 6794499 (2004-09-01), Wengel et al.
patent: 7034133 (2006-04-01), Wengel et al.
patent: 2002/0068708 (2002-06-01), Wengel et al.
patent: 2003/0082807 (2003-05-01), Wengel
patent: 2003/0087230 (2003-05-01), Wengel
patent: 2003/0134808 (2003-07-01), Wengel et al.
patent: 2003/0144231 (2003-07-01), Wengel et al.
patent: 2004/0143114 (2004-07-01), Imanishi et al.
patent: 2005/0287566 (2005-12-01), Wengel et al.
patent: 2007/0117773 (2007-05-01), Koizumi et al.
patent: 1 013 661 (2000-06-01), None
patent: WO 94/08003 (1994-04-01), None
patent: WO 96/31557 (1996-10-01), None
patent: WO 98/39352 (1998-09-01), None
patent: WO 99/14226 (1999-03-01), None
patent: WO 01/18015 (2001-03-01), None
Obika S., et al., “Synthesis of 2′-O, 4′-C-Methyleneuridine and -cytidine. Novel Bicyclic Nucleosides Having a Fixed C1-endo Sugar Puckering”,Tetrahedron Letters, (1997), 38(50), 8735-8738.
Nielsen P, et al., “Synthesis of 2′-O,3′-C-Linked Bicyclic Nucleosides and Bicyclic Oligonucleotides”,J. Chem. Soc., Perkin Trans. 1, (1997) 3423-3433.
Singh S.K., et al., “LNA (Locked Nucleic Acids) : Synthesis and High-Affinity Nucleic Acid Recognition”,Chem. Commun., (1998), 455-456.
Koshkin A.A., et al., “LNA (Locked Nucleic Acids) : Synthesis of the Adenine, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers, Oligomerisation, and Unprecedented Nucleic Acid Recognition”,Tetrahedron, (1998), 54, 3607-3630.
Singh S.K. et al., “University of LNA-Mediated High-Affinity Nucleic Acid Recognition”,Chem. Commun., (1998), 1247-1248.
Christensen N.K. et al., “A Novel Class of Oligonucleotide Analogues Containing 2′-O,3′-C-Linked (3.2.0) Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and Molecular Modeling”,J. Am. Chem. Soc., (1998), 120, 5458-5463.
Koshkin A.A., et al., “Synthesis of Novel 2′,3′-Linked Bicyclic Thymine Ribonucleosides”,J. Org. Chem., (1998), 63, 2778-2781.
Ezzitouni A., et al., “Conformationally Locked Carbocyclic Nucleosides Built on a Bicyclo(3.1.0)Hexane Template with a Fixed Southern Conformation. Synthesis and Antiviral Activity”,J. Chem. Soc., Perkins Trans. 1, (1997), 1073-1078.
Freier S.M., et al., “The Ups and Downs of Nucleic Acid Duplex Stability: Structure-Stability Studies on Chemically-Modified DNA:RNA Duplexes”,Nucleic Acids Research, (1997), 25(22), 4229-4443.
Satoshi Obika et al., “Preparation and Properties of 2′,5′-Linked Oligonucleotide Analogues Containing 3′-O,4′-C-Methyleneribonucleosides”,Bioorganic&Medicinal Chemistry Letters, 9 (1999), 515-518.
S. Obika, D. Nanbu, K. Morio and T. Imanishi, “Synthesis and Properties of Oligonucleotides Containing Novel Bicyclic Nucleosides with a Fixed N-Form Sugar Puckering” Summary of Poster No. 32 of the 7thSymposium on Antisense, Nov. 21, 1997, Chiba City, Japan.
S. Obika, K. Morio, D. Nanbu and T. Imanishi, “Duplex and Triplex Formation of 2′, 5′-Linked Oligonucleotide Analogs Having Restricted Sugar Puckering in S-Conformation”, Summary of Poster No. 33 of the 7thSymposium on Antisense, Nov. 21, 1997, Chiba City, Japan.
Koshkin A.A., et al., “Novel Convenient Syntheses of LNA [2.2.1]Bicyclo Nucleosides”,Tetrahedron Letters, (1998), 39, 4381-4384.
Wengel, “LNA (Locked Nucleic Acids) : Synthesis and High-Affinity Nucleic Acid Recognition—Stop the Twisting!”, National Seminar on Perspectives in Interfacial Areas of Chemistry and Biology, Delhi University, Jan. 20-22, 1998.
Imanishi, T., “Synthesis and Property of Novel Conformationally Constrained Nucleoside and Oligonucleotide Analogs”, The Sixteenth International Congress of Heterocyclic Chemistry, Aug. 10-15, 1997.
S. Obika, K. Morio, Y. Hari and T. Imanishi, “Facile Synthesis and Conformation of 3′-O,4′-C-Methyleneribonucleosides,”Chem. Commun., 2423-2424 (1999).
S. Obika, D. Nanbu, K. Morio and T. Imanishi, “Synthesis and Properties of Oligonucleotides Containing Novel Bicyclic Nucleosides with a Fixed N-Form Sugar Puckering,” Poster No. 32 of the 7th Symposium on Antisense, Nov. 21, 1997, Chiba City, Japan.
Griffiths et al, “Keratinocyte Intercellular Adhesion Molecule-1 (ICAM-1) Expression Precedes Dermal T Lymphomatic Infiltration . . . ”,American Journal of Path., Dec. 1989, vol. 135, No. 6, pp. 1045-1053.
Thuong et al, “Sequence-Specific Recognition and Modification of Double-Helical DNA by Oligonucleotides”,Angew. Chem. Int. Ed. Engl., 1993, 32, pp. 666-690.
Manoharan et al, “Chemical Modifications to Improve Uptake and Bioavailability of Antisense Oligonucleotides”,Ann. N.Y. Acad. of Sciences, 1992, 660, pp. 306-309.
Stetler-Stevenson et al, “Tumor Cell Interactions With the Extracellular Matrix During Invasion and Metastasis”,Annu. Rev. Cell Biol., 1993, 9, pp. 541-573.
Cook, “Medicinal chemistry of antisense oligonucleotides—future opportunities”,Anti-Canceer Drug Design, 1991, 6, pp. 585-607.
Sanghvi, “Heterocyclic Base Modifications in Nucleic Acids and Their Applications in Antisense Oligonucleotides”,Antisense Research and Applications, 1993, Chapter 15, pp. 273-288.
Shiohara et al, “Fixed Drug Eruption”,Arch Dermatol., Oct. 1989, vol. 125, pp. 1371-1376.
Mishra et al, “Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery”,Biochim. Biophys. Acta, 1995, 1264, pp. 229-237.
Svinarchuk et al, Inhibition of HIV proliferation in MT-4 cells by antisense oligonucleotide conjugated to lipophilic groups,Biochimie, 1993, 75, pp. 49-54.
Manoharan et al, “Introduction of a Lipophilic Thioether in the Minor Groove of Nucleic Acids for Antisense Applications”,Bioorg. Med. Chem. Lett., 1993,

Affiliated with

Also associated with

Rating

Nucleoside and oligonucleotide analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleoside and oligonucleotide analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleoside and oligonucleotide analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3914805