Nucleoside analogs and oligonucleotide derivatives...

Details Nucleoside analogs and oligonucleotide derivatives... Nucleoside analogs and oligonucleotide derivatives...

2006-05-30

2006-05-30

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S026700, C536S026800, C536S026900, C536S027200, C536S028400

Reexamination Certificate

active

07053199

ABSTRACT:
Nucleoside analogues expressed by the following general formulawhere B represents an aromatic base having carbonyl oxygen at the 2-position, or a 2-hydroxyphenyl group, or oligonucleotide derivatives containing one or more of the nucleoside analogues are provided.The oligonucleotide derivatives are triplex-forming oligonucleotide derivatives which bind specifically to target double-stranded DNA with high affinity in the antigene method to form triplexes, and can thereby control and inhibit the expression of relevant genes efficiently, and which show high resistance to nucleases.

REFERENCES:
patent: 6268490 (2001-07-01), Imanishi et al.
Yoon et al., Elucidation of the sequence-specific third-strand recognition of four Watson-crick base pairs in a pyrimidine triple-helix motif: T•AT, C•GC, T•G, and G•TA.Proc. Natl. Acad. Sci. USA, 89:3840-3844 (1992).
Povsic et al., Triple helix formation by oligonucleotides on DNA extended to the physiological pH range,J. Am. Chem. Soc., 111(8):3059-3061 (1989).
Chan et al., Triplex DNA: fundamentals, advances, and potential applications for gene therapy,J. Mol. Med., 75:267-282 (1997).

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