Nucleoside analogs

Details Nucleoside analogs Nucleoside analogs

1995-06-07

1998-03-10

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546 23, C07F 96561, C07F 96558, C07F 96512, A61K 31675

Patent

active

057261741

ABSTRACT:
Provided are compounds of the following formulae:

REFERENCES:
patent: 3457255 (1969-07-01), Jones et al.
patent: 4724233 (1988-02-01), De Clercq et al.
patent: 4808716 (1989-02-01), Holy et al.
patent: 4977144 (1990-12-01), Fujimoto et al.
patent: 5066654 (1991-11-01), Taylor, Jr. et al.
patent: 5142051 (1992-08-01), Holy et al.
patent: 5223499 (1993-06-01), Greenlee et al.
patent: 5470857 (1995-11-01), Borcherding et al.
Rosenberg, Coll. Czech. Chem. Commun. 50, 1507 (1985).
Bronson et al., "Synthesis and Antiviral Activity of Phosphonylmethoxyethyl Derivatives of Purine and Pyrimidine Bases," J 72-87 (1989) in Nucleoside Analogs.
Chow et al., "Stereospecific Vorbruggen-like Reactions of 1,2-Anhydro Sugars--An Alternative Route to the Synthesis of Nucleosides," J Org Chem 55:4211-4214 (1990).
Chu et al, "Chemistry and Antiviral Activities of Acyclonucleosides," J Het Chem 23:289-319 (1986).
De Clercq et al, "A novel selective broad-spectrum anti-DNA virus agent," Nature 323:464-467 (1986).
Dvorakova, "Synthesis and Biological Effects of 9-(3-Hydroxy-2-Phosphonomethoxypropyl) Derivatives of Deazapurine Bases," Collect Czech Chem Commun 58:1403-1418 (1993).
Dvorakova et al, "Synthesis and Biological Effects of N-(20Phosphonomethoxyethyl) Derivatives of Deazapurine Bases," Collect Czech Chem Commun 58:1419-1429 (1993).
Foguet et al., "Process for the Preparation of 9-(2-Hydroxyethoxymethyl) guanine, used as an Antiviral Agent," Chem Ab 107:236377g (1989).
Ho et al., "Cellular Metabolism and Enzymatic Phosphorylation of Anti-HIV Agent," Antiviral Res 17:66 (1992).
Holy et al., "3'-0-Phosphonylmethyl-9-(S)-(2,3-dihydroxypropyl)adenine novel type of biologically active nucleotide analogue," Nuc Acids Res 14:277-278 (1984).
Holy et al., "Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues," Am Chem Soc Symposium Series 401 4:51-71 (1989).
Kaneko, Y., "Light Fading Inhibitor for Color Photographic Material," Chem Ab 111:205325s (1989).
Kim et al, "A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents," J Med Chem 34(7):2286-2294 (1991).
Kim et al, "Regiospecific and Highly Stereoselective Electrophilic Addition to Furanoid Glycals: Synthesis of Phosphonate Nucleotide Analogues with Potent Activity against HIV," J Org Chem 56:2642-2647 (1991).
Kim et al, "Synthesis of a phosphonate isostere of acyclovir monophosphate: a herepesvirus active phosphonate nucleotide analogue," Heterocycles 31(9):1571-1574 (1990).
Kim et al, "Synthesis of a phosphonate isostere of ganciclovir monophosphate: a highly cytomegalovirus active phosphonate nucleotide analogue," Tet Lett 31:3257 (1990).
Kim et al., "Synthesis and anti-HIV Activity of Bioorg Med Chem Lett 2:307-310 (1992).
Kim et al., "Synthesis and HIV Activity of Phosphonate Isosteres of D5T Monophosphate," Bioorg Med Chem Lett 2:367-370 (1992).
Prisbe et al., "Synthesis and Antiherpes Virus Activity of Phosphate and Med Chem 29:671-675 (1986).
Robins et al., "Synthesis, Transformation Chemistry, and Biological Activity of Guanine Nucleosides and Analogues," Nucls & Nuclt 8:725-741 (1989).
Rosenberg et al, "Phosphonylmethoxyalkyl and Phosphonylalkyl Derivatives of Adenine," Collect Czech Chem Commun 53:2753-2777 (1988).
Sergheraert et al., "Synthesis and Anti-HIV Evaluation of D4T and D4T 5'-Monphosphate Prodrugs," J Med Chem 36:826-830 (1993).
Yokota et al, "Inhibitory effects of acyclic nucleoside phosphonate analogues on hepatitis B virus DNA synthesis in HB611 cells," Antiviral Chem & Chemo 5(2):57-63 (1994).
Zemlicka et al., "Nucleosides. XV. Decarboxylative Elimination of 2'-Deoxynucleoside Uronic Acids," J Am Chem Soc 94:3213-3218 (1972).
Borthwick et al, Tet Lett, 31:767 (1990).
Kowollik et al., "Ungesattigte Halogenzucker-Nucleoside Des Thymins (1)," Tet Lett 22:1737-1740 (structures only) (1971).
Spector et al., "Conversion of 2,6-Diamino-9-(2-Hydroxyethoxymethyl)Purine to Acyclovir as Catalyzed by Adenosine Deaminase," Biochem Pharm 32(17):2505-2509 (1983).
Townsend (Ed.), "Chemistry of Nucleosides & Nucleotides," 1:159, 241, 242, and 279 (1988).
Townsend (Ed.), "Chemistry of Nucleosides & Nucleotides," 3:318, 319, 416 (1994).
Yang et al., "New antiretroviral agent: I)4A-monophosphonate," Journal of Acquired Immune Deficiency Syndromes 4(3):360 (1991).
Breaker et al., "Polynucleotide phosphorylase forms polymers from an ADP analog in which the 5' oxygen is replaced by a methylene group," Nuc Acids Res 18:3085-3086 (1990).
Coe et al., "Preparation of Nucleotide Mimics with Potent Inhibitory Activity Against HIV Reverse Transcriptase," J Chem Soc Perkin Trans I 3378-3379 (1991).
Frick et al., "Carbocyclic Nucleosdie 5'-Phosphonates," IUB Conference on Nucleic Acid Therapeutics p. 63 (1991).
Heinemann et al., "Effect of a single 3'-methylene phosphonate linkage on the conformation of an A-DNA octamer double helix," Nuc Acids Res 19(3):427-433 (1991).
Mazur et al., "Isosteres of Natural Phosphates. 11. Synthesis of a Phosphonic Acid Analogue of an Oligonucleotide," Tet Lett 40:3949-3956 (1984).
Morr et al., "Uber die Synthese von 2',3'-Didesoxy-3'-(phosphoriomethyl)nucleosiden, Phosphonat-Analogen von 2'-Desoxy-3'-nucleotiden," Lebigs Ann. Chem pp. 615-631 (1991).

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