Nucleophilic substitution process combined with additional react

Details Nucleophilic substitution process combined with additional react Nucleophilic substitution process combined with additional react

1984-08-10

1986-04-08

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548565, 560 20, 560102, 560 47, 560 19, 562469, C07D20946, C07D20718, C07C 7946

Patent

active

045814635

ABSTRACT:
Halonitroarylacetic acid esters are prepared by reacting a halonitroaromatic compound with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The halonitroarylacetic acid esters formed by the process can be readily converted into derivatives, such as pharmaceuticals.

REFERENCES:
patent: 3868391 (1975-02-01), Carney et al.
patent: 4239901 (1980-12-01), Rainer
Golinski et al., Tetrahedron Letters, No. 37 (1978), 3495-3498.
Makosza et al., (I), Jour. Org. Chem., vol. 45 (180), 1534-1535.
House--Modern Synthetic Reactions (1972), 494.
Carney et al., (II), Experientia, vol. 29 (1973), 938.
Makosza (II), Int. Conf. Chem. Biotechnol. Biol. Act. Nat. Prod. (Proc.), 1st (1981), issue 2, 480-490.

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