Nucleophilic substitution process

Details Nucleophilic substitution process Nucleophilic substitution process

1983-04-21

1985-03-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C12150

Patent

active

045029997

ABSTRACT:
In a process for preparing a 2-(fluoronitrobenzene)acetonitrile by reacting a fluoronitrobenzene with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base, a solvent having a dipole moment not higher than about 2.0 debyes is used to lead to the formation of a 2-(fluoro-2-nitrobenzene)acetonitrile. Preferred reactants are 2-fluoronitrobenzene and 2-chloropropionitrile, which lead to the formation of 2-(3-fluoro-2-nitrobenzene)propionitrile.

REFERENCES:
patent: 4370278 (1983-01-01), Stahly et al.
Golinski et al., Tetrahedron Letters, vol. 37, pp. 3495-3498, (1978).
Makosza et al., J. Org. Chem., vol. 45, pp. 1534-1535, (1980).
Makosza, Int. Conf. Chem. Biotechnol. Biol. Act. Nat. Prod. (Proc.), vol. 2, pp. 480-490, (1981).

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