Nucleophilic substitution process

Details Nucleophilic substitution process Nucleophilic substitution process

1983-03-10

1985-03-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465G, 260465F, C07C12150

Patent

active

045029989

ABSTRACT:
Nitrophenoxy- or phenylthiobenzeneacetonitriles are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-dinitrosubstituted acetonitrile in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.

REFERENCES:
patent: 3600437 (1971-08-01), Marshall
Golinski et al., Tetrahedron Letters, vol. 37, pp. 3495-3498, (1978).
Makosza et al., J. Org. Chem., vol. 45, pp. 1534-1535, (1980).
Makosza, Int. Conf. Chem. Biotechnol. Biol. Act. Nat. Prod. (Proc.), vol. 2, pp. 480-490, (1981).

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