Nucleophilic substitution process

Details Nucleophilic substitution process Nucleophilic substitution process

1982-12-23

1985-03-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C12150

Patent

active

045029962

ABSTRACT:
Halonitroarylacetonitriles are prepared by reacting a halonitroaromatic compound wherein the halo substituent has an atomic number of at least 17 with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the halonitroaromatic compound during which an alpha-substituent functions as a leaving group. The halonitroarylacetonitriles formed by the process can be readily converted into derivatives, such as pharmaceuticals.

REFERENCES:
Golinski et al., Tetrahedron Letter No. 37, pp. 3495-3498 (1978).
Makosza et al., J. Org. Chem., vol. 45, pp. 1534-1535 (1980).
Mokosza, Int. Conf. Chem. Biotechol. Biol. Act. Nat. Prod. (Proc.), vol. 2, pp. 480-490 (1981).

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