Nucleophilic substitution process

Details Nucleophilic substitution process Nucleophilic substitution process

1983-03-10

1985-04-16

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 21, 560 23, 560 9, 562431, 562435, C07C 7946

Patent

active

045117292

ABSTRACT:
Nitrophenoxy- or nitrophenylthiobenzeneacetic acid esters are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.

REFERENCES:
Golinski, J. et al., Tetrahedron Letters, No. 37, pp. 3495-3498, 1978.
J. O. Chem., 1980, 45, 1534-1535.
Int. Conf. Biotechnol. Biol. Acta. Nat. Pred. (Proc.) 1st 1981, Issue 2, pp. 480-490.

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