Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1994-08-18
1996-07-23
Spiegel, Carol A.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
435 71, 435 74, 435 6, 436500, 436505, 436518, 436544, 436546, 436800, 436817, 546107, G01N 33566
Patent
active
055389015
ABSTRACT:
This invention is directed to the novel assay methods utilizing nucleophilic polysubstituted aryl acridinium ester conjugates as the tracers. Conjugates prepared by covalent coupling of novel nucleophilic polysubstituted aryl acridinium esters with biological compounds including small organic molecules such as Vitamin B12, folate, cortisol, estradiol, and thromboxane B2, were found useful in the development of highly sensitive assays for the analytes of diagnostic interest.
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Chang Steve C. S.
Klukas Carol K.
Law Say-Jong
Vitkauskas Christine A.
Ciba Corning Diagnostics Corp.
Morgenstern Arthur S.
Roesler Judith A.
Spiegel Carol A.
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