Nucleophile substituted ecteinascidins and N-oxide ecteinascidin

Details Nucleophile substituted ecteinascidins and N-oxide ecteinascidin Nucleophile substituted ecteinascidins and N-oxide ecteinascidin

1998-04-10

1999-11-16

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544233, 544340, A01N 4358, C07D23726, C07D24136

Patent

active

059858761

ABSTRACT:
Five new nucleophile substituted ecteinascidin (Et) compounds have been isolated from extracts of Ecteinascidia turbinata. These compounds have been purified by chromatographic techniques and their structures and bioactivities have been determined. The five nucleophile substituted Et compounds have been designated herein as Et 802 (1), Et 788 (2), Et 760 (3), Et 858 (4) and Et 815 (5). Also obtained were three new N-oxide ecteinascidin compounds, which have been designated herein as Et 717 (6), Et 775 (7) and Et 789 (8). Some of these newly discovered Et compounds show exceedingly potent cytotoxicity against L1210.

REFERENCES:
patent: 4273773 (1981-06-01), Demerson et al.
patent: 5089273 (1992-02-01), Rinehart et al.
patent: 5459141 (1995-10-01), Vertesy et al.
patent: 5484717 (1996-01-01), Zaccardi
Sakai et al., "Ecteinascidins: Putative Biosynthetic . . . ", J. Am. Chem. Soc., 1996, vol. 118, pp. 9017-9023.

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