Nucleic acids vectors and host cells encoding and expressing her

Details Nucleic acids vectors and host cells encoding and expressing her Nucleic acids vectors and host cells encoding and expressing her

1994-10-25

1998-11-10

Arthur, Lisa B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 912, 435325, 4352523, 4353201, 536 235, 536 2431, 536 2433, 935 77, 935 78, C12N 1500, C12N 1585, C12N 700, C12N 1563, C07H 2104

Patent

active

058342290

ABSTRACT:
Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.

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