Nucleic acids that encode peptides which modulate apoptosis

Details Nucleic acids that encode peptides which modulate apoptosis Nucleic acids that encode peptides which modulate apoptosis

1997-08-08

1999-01-26

McKelvey, Terry A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435243, 4353201, 435410, 536 235, 536 2431, C12N 510, C12N 100, C12N 1512, C12N 1563

Patent

active

058637958

ABSTRACT:
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain," which is essential both to Bak's interaction with Bcl-x.sub.L, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.

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