Nucleic acids proteins of a D. melanogaster insulin-like gene an

Details Nucleic acids proteins of a D. melanogaster insulin-like gene an Nucleic acids proteins of a D. melanogaster insulin-like gene an

1998-11-30

2000-10-24

Chambers, Jasemine

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435 691, 435 694, 4353201, 435325, 435348, C07H 2104

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061359424

ABSTRACT:
The present invention relates to a D. melanogaster insulin-like gene and methods for identifying insulin-like genes. The methods provide nucleotide sequences of a D. melanogaster insulin-like gene, amino acid sequences of the encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a D. melanogaster insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out). Still further, methods to identify a D. melanogaster gene which modifies the function of, and/or functions in a signaling pathway with, an insulin-like gene are provided. The invention further provides uses of Drosophila insulin-like nucleic acids and proteins, e.g., as a media additive, and as a pesticide.

REFERENCES:
Harvey et al . Gene Bank Accession #AA140991. Submitted 1997.
Casal J. And Leptin M. Proc. Natl. Acad. Sci. USA 93:10327-10322.1996.
http://www.fruitfly.org/ Berkeley Drosophila Genome Project (Berkeley Fly Database) results of search for STS Dm3500.
Casal and Leptin GenBank Accession #W91831 Aug. 10, 1998.
Harvey et al. GenBank Accession #AA140991 Jan. 12, 1998.

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