Nucleic acids, polypeptides, compositions, and methods for...

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S430100, C435S440000

Reexamination Certificate

active

10141647

ABSTRACT:
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

REFERENCES:
patent: 5328999 (1994-07-01), Bennett et al.
patent: 5849587 (1998-12-01), Hanauske-Abel et al.
patent: 6020139 (2000-02-01), Schwartz et al.
patent: 6124091 (2000-09-01), Petryshyn
patent: 6214572 (2001-04-01), Yuan et al.
patent: 2003/0050272 (2003-03-01), Taylor et al.
patent: 2003/0144238 (2003-07-01), Thompson et al.
patent: WO 96/25492 (1996-08-01), None
patent: WO 96/41639 (1996-12-01), None
patent: WO 99/01551 (1999-01-01), None
patent: WO 01/02592 (2001-01-01), None
patent: WO 01/10906 (2001-02-01), None
patent: WO 03/10286 (2003-02-01), None
Anderson (Nature 1998; 392(suppl):25-30).
Dang et al. (Clinical Cancer Research 1999; 5:471-474).
Levine et al. (Molecular Medicine Today 1999; 5:165-171).
Chang et al., “Proteases for Cell Suicide: Functions and Regulation of Caspases,” Microbiology and Molecular Biology Reviews, vol. 64 (2000), pp. 821-846.
Creagh et al., “Caspases: Cellular Demolition Experts,” Biochemical Society Transactions, vol. 29 (2001), pp. 696-702.
Evan et al., “Apoptosis and the Cell Cycle,” Current Opinion in Cell Biology, vol. 7 (1995), pp. 825-834.
Hickman, “Apoptosis and Chemotherapy Resistance,” European Journal of Cancer, vol. 32A (1996), pp. 921-926.
Müllauer et al., “Mutations in Apoptosis Genes: A Pathogenetic Factor for Human Disease,” Mutation Research, vol. 488 (2001), pp. 211-231.
Reed et al., “Drug Discovery Opportunities from Apoptosis Research,” Current Opinion in Biotechnology, vol. 11 (2000), pp. 586-592.
Reed, “Bcl-2 Family Proteins: Regulations of Chemoresistance in Cancer,” Toxicology Letters, vol. 82/83 (1995), pp. 155-158.
Salomons et al., “The Baxa:Bcl-2 Ratio Modulates The Response to Dexamethasone in Leukaemic Cells and is Highly Variable in Childhood Acute Leukaemia,” International Journal of Cancer, vol. 71 (1997), pp. 959-965.
Schmitt et al., “Apoptosis and Therapy,” Journal of Pathology, vol. 187 (1999), pp. 127-137.
Schuler et al., “Mechanism of p53-Dependent Apoptosis,” Biochemical Society Transactions, vol. 29 (2001), pp. 684-688.
Wallace-Brodeur et al., “Clinical Implications of p53 Mutations,” Cellular and Molecular Life Sciences, vol. 54 (1999), pp. 64-75.
Hannun, “Apoptosis and the Dilemma of Cancer Chemotherapy,” Blood, vol. 89 (1997), pp. 1845-1853.
Bevec, Dorian et al., “Eukaryotic Initiation Factor 5A Activity and HIV-1 Rev Function,”Biological Signalsvol. 6:124-133 (1997).
Chen, Kuang Yu et al., “Biochemistry and Function of Hypusine Formation on Eukaryotic Initiation Factor 5A,”Biological Signalsvol. 6:105-109 (1997).
Gallie, Danierl R., “A tale of two termini: A functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation,”Genevol. 216:1-11 (1998).
Goyns, M. H., “The Role of Polyamines in Animal Cell Physiology,”J. theor. Biol. vol. 97:577-589 (1982).
Igarashi, Kazuei et al., “Increase of Fidelity of Polypeptide Synthesis by Spermidine in Eukaryotic Cell-Free Systems,”Eur. J. Biochemvol. 128:597-604 (1982).
Klein, T. M. et al., “Factors Influencing Gene Delivery into Zea Mays Cells by High-Velocity Microprojectiles,”Bio/Technologyvol. 6:559-563 (1988).
Murphey, Roberta J. et al., “Hypusine Formation in Protein by a Two-step Process in Cell Lysates,”The Journal fo Biological Chemistryvol. 262, No. 31:15033-15036 (1987).
Murphey, Roberta J. et al., “Hypusine Biosynthesis in Protein and its Biological Consequences”.
Park, Myung Hee et al., “The Biosynthesis of Hypusine (Ne-(4-Amino-2-hydroxybutyl)lysines); Alighment of the Butylamine Segment and Source of the Secondary Amino Nitrogen,”The Journal of Biological Chemistryvol. 259, No. 19:12123-12127 (1984).
Park, M. H. et al., “Is hypusine essential for eukaryotic cell proliferation?”TIBSvol. 18:475-479 (1993).
Park, Myung Hee et al., “Cell-free Synthesis of Deoxyhypusine; Separation of Protein Substrate and Enzyme and Identification of 1, 3-Diaminopropane as a Product of Spermidine Cleavage,”The Journal of Biological Chemistryvol. 263, No. 30:15264-15269 (1988).
Park, Myung Hee et al., “Comparison of the Activities of Variant Forms of elF-4D,”The Journal of Biological Chemistryvol. 266, No. 13:7988-7994 (1991).
Park, Myung Hee et al., “The Biosynthesis of Protein-bound Hypusine (Ne-(4-Amino-2-hydroxybutyl)Lysine); Lysine as the Amino Precursor and the Intermediate Role of Deoxyhypusine (Ne-(4-Amino-2-hydroxybutyl)Lysine),”The Journal of Biological Chemistryvol. 257, No. 12:7217-7222 (1982).
Park, Myung Hee et al., “Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor,”Proc. Natl. Acad. Sci.USA vol. 78, No. 5:2869-2873 (1981).
Pena, A. de la et al., “Transgenic rye plants obtained by injecting DNA into young floral tillers,”Naturevol. 325:274-276 (1987).
Rhoads, Robert E., “Regulation of Eukaryotic Protein Synthesis by Initiation Factors,”The Journal of Biological Chemistryvol. 268, No. 5:3017-3020 (1993).
Tome, Margaret E. et al., “Cellular Eukaryotic Initiation Factor 5A Content as a Mediator of Polyamine Effects on Growth and Apoptosis,”Biological Signalsvol. 6:150-156 (1997).
Wolff, Edith C. et al., “Cleavage of Spermidine as the First Step in Deoxyhypusine Synthesis, the Role of Nad+,”The Journal of Biological Chemistryvol. 265, No. 9:4793-4799 (1990).
Zuk, Dorit et al., “A single amino acid substitution in yeast eIF-5A results in mRNA stabilization,”The EMBO Journalvol. 17, No. 10:2914-2925 (1998).
Bevec, D. et al., “Molecular characterizatin of cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus,”FEB Lett. vol. 378:195-198 (1996).
Brach, Marion A., “The Mitogenic Response to Tumor Necrosis Factor Alpha Requires c-Jun/AP-1,”Molecular and Cellular Biologyvol. 13, No. 7:4284-4290 (1993).
Cohen, Seymour S., “Growth of Studies on Hypusine in Biological Systems,”Biol Signalsvol. 6:110-114 (1997).
Corpet, Florence, “Multiple sequence alignment of hierarchical clustering,”Nucleic Acids Researchvol. 16, No. 22:10880-10890 (1988).
Joe, Young Ae et al., “Cloning and Expression of Human Deoxyhypusine Synthase cDNA: Structure-Function Studies with the Recombinant Enzyme and Mutant Proteins,”The Journal of Biological Chemistryvol. 270, No. 38:22386-22392 (1995).
Morton, R. et al., “Gene replacement,”Molecular Breedingvol. 1:123-132 (1995).
Nierlich, Donald P. et al., “Molecular Mechanisms in the Control of Gene Expression,”ICN-UCLA Sumposia on Molecular and Cellular Biologyvol. 5 (1976).
Park, Myung Hee et al., “Hypusine Is Essential for Eukaryotic Cell Proliferation,”Biological Signalsvol. 6:115-123 (1997).
Park, Myung Hee et al., “Deoxypusine Synthase Activity Is Essential for Cell Viability in the YeastSaccharomyces cerevisiae,”The Journal of Biological Chemistryvol. 273, No. 3:1677-1683 (1998).
Park, Myung Hee et al., “Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation,”BioFactorsvol. 4, No. 2:95-104 (1993).
Ranu, Rajinder Singh et al., “Regulation of Protein Synthesis in Rabbit Reticulocyte Lysates: Preparation of Ef

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids, polypeptides, compositions, and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids, polypeptides, compositions, and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids, polypeptides, compositions, and methods for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3774241

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.